Zephaniah Mayhew was born 1686 in Chilmark, Dukes County, Massachusetts to Thomas Mayhew (1650-1688) and Sarah Skiffe (1646-1742) and died 20 November 1733 Chilmark, Dukes County, Massachusetts of unspecified causes. He married Bethia Wadsworth (1674-) March 1711 in Chilmark, Dukes County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Abiah Mayhew (1712-1809) | |||
| Abonijah Mayhew (1713-1714) | |||
| Zephaniah Mayhew (1715-1751) | |||
| Jerusha Mayhew (1717-1793) | |||
| Jedidah Mayhew (1719-1788) | |||
| Mary Mayhew (1721-1795) | |||
| Bethiah Mayhew (1723-) | |||
| Mercy Mayhew (1725-1807) | |||
Siblings