Thomas Gold Appleton was born 31 March 1812 in Cambridge, Middlesex County, Massachusetts to Nathan Appleton (1779-1861) and Maria Theresa Gold (1786-1833) and died 17 April 1884 New York City, New York of unspecified causes.
Siblings
| Name | Birth | Death | Joined with |
| Thomas Gold Appleton (1812-1884) | 31 March 1812 Cambridge, Middlesex County, Massachusetts | 17 April 1884 New York City, New York | |
| Mary Appleton (1813-1889) | 18 October 1813 Boston, Suffolk County, Massachusetts | 1889 United States | Robert James Mackintosh (1811-1864) |
| Charles Sedgwick Appleton (1815-1835) | |||
| Frances Elizabeth Appleton (1817-1861) | 6 October 1817 Boston, Suffolk County, Massachusetts | 10 July 1861 Cambridge, Middlesex County, Massachusetts | Henry Wadsworth Longfellow (1807-1882) |
| George William Appleton (1826-1827) | |||
| Name | Birth | Death | Joined with |
| William Sumner Appleton (1840-1903) | 11 January 1840 Boston, Suffolk County, Massachusetts | 28 April 1903 Boston, Suffolk County, Massachusetts | Edith Ida Stuart Appleton (1849-1892) |
| Harriet Sumner Appleton (1841-1923) | 16 November 1841 Boston, Suffolk County, Massachusetts | 8 April 1923 Cambridge, Middlesex County, Massachusetts | Greeley Stevenson Curtis (1830-1897) |
| Nathan Appleton (1843-1906) | |||