Samuel Sprague, Jr. was born October 1673 in Marshfield, Plymouth County, Massachusetts to Samuel Sprague (1640-1709) and Sarah Chillingsworth (1642-1725) and died 15 February 1764 Duxbury, Plymouth County, Massachusetts of unspecified causes. He married Bethiah Thomas (1681-1761) 1700 in Duxbury, Plymouth County, Massachusetts.
The two oldest sons of Samuel, Samuel Jr and John, moved to Duxbury, Massachusetts before 1710 and lived on adjoining farms in the area called "Sprague's Neck", which they inherited from their father, some 230 acres. The land, beginning at a point near what is now known as Sprague's Wharf, the boundary ran along the shore to Blue-fish River, then up the river to the neighborhood of John Alden (1622-1701)'s thence by land of Jacob Smith to meet a line which ran westaward by the sites of the village schoolhouse and the Methodist Church to the house of Daniel Glass. The two farms were divided by the road now called Harrison Street.