In September 1834 Knights' wife Sally died after giving birth to a baby boy, Eli, who also died the same day at Gallatin Township, Clay County, Missouri Territory. On the November 24, 1834 Knight married Lydia Goldthwaite Bailey at Kirtland, Ohio. This was the first marriage performed by Joseph Smith.
In both Missouri and later at Nauvoo, Illinois, Knight constructed mills. In 1846–1847, Knight was involved with George Miller in the Ponca Encampment. Knight died at what is today Knox County, Nebraska.
Among his nine children was Jesse Knight.
Family of Newel Knight & Lydia Goldthwaite
- Sally Knight (1836-1916) - md Zemira Palmer, a Mormon Battalion Veteran
- James Philander Knight (1838-1909) -
- Joseph Ether Knight (1840-1878) - md Elizabeth S Jones
- Newel Knight (1842-1907) -
- Lydia Knight (1844-1905) - md John Ray Young
- Jesse Knight (1845-1921) - md Amanda McEwan
- Esther Knight (1847-1882) - ???
- Jane Knight (1847-1882) - ???
- Hyrum Helaman Knight (1847-1880) -
|Offspring of Newel Knight and Lydia Goldthwaite (1812-1884)|
|Sally Knight (1836-1916)||1 December 1836 Gallatin, Daviess County, Missouri, United States||1 October 1916 Orderville, Kane County, Utah, United States|| Zemira Palmer (1831-1880)|
|James Philander Knight (1838-1909)|| |
|Joseph Ether Knight (1840-1878)||18 October 1840 Nauvoo, Hancock County, Illinois, United States||28 June 1878 Sunset, Yavapai County, Arizona, United States|| Jane Lucinda Judd (1849-1918)|
|Newel Knight (1842-1907)|| |
|Lydia Knight (1844-1905)|| |
|Jesse Knight (1845-1821)|| |
|Esther Knight (1847-1882)|| |
|Jane Knight (1847-1882)|| |
|Hyrum Helaman Knight (1847-1880)|