In biology and evolutionary computation, a locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map. Gene mapping is the process of determining the locus for a particular biological trait.
Nomenclature[edit | edit source]
The chromosomal locus of a gene might be written "6p21.3".
|6||The chromosome number.|
|p||The position is on the chromosome's short arm (p for petit in French); q indicates the long arm.|
|21.3||The numbers following the letter represent the position on the arm: band 21, sub-band 3. The bands are visible under a microscope when the chromosome is suitably stained. Each of the bands is numbered, beginning with 1 for the band nearest the centromere. Sub-bands and sub-sub-bands are visible at higher resolution.|
A range of locations is specified in a similar way. For example, the locus of gene OCA1 may be written "11q1.4-q2.1", meaning it is on the long arm of chromosome 11, somewhere in the range of sub-band 4 of band 1, and sub-band 1 of band 2.
The ends of a chromosome are labeled "ptel" and "qtel", and so "2qtel" refers to the telomere of the long arm of chromosome 2.
[edit | edit source]
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