James Douglas-Hamilton, 5th Duke of Hamilton was born 5 January 1703 to James Douglas-Hamilton, 4th Duke of Hamilton (1658-1712) and Elizabeth Gerard (c1681-1744) and died 2 March 1743 Bath, Somerset, England, United Kingdom of unspecified causes. He married Anne Cochrane (1707-1724) 14 February 1723 . He married Elizabeth Strangways (c1694-1729) 1727 . He married Anne Spencer (1720-1771) 21 August 1737 .
|Offspring of James Douglas-Hamilton, 5th Duke of Hamilton and Anne Cochrane (1707-1724)|
|James Douglas-Hamilton, 6th Duke of Hamilton (1724-1758)||5 July 1724||17 January 1758 Great Tew, Oxfordshire, England, United Kingdom||Elizabeth Gunning, 1st Baroness Hamilton (c1733-1790)|
|Offspring of James Douglas-Hamilton, 5th Duke of Hamilton and Anne Spencer (1720-1771)|
|Anne Douglas-Hamilton (1738-1780)|
|Archibald Douglas-Hamilton, 9th Duke of Hamilton (1740-1819)||15 July 1740 Hamilton, Lanark, Scotland, United Kingdom||16 February 1819||Harriet Stewart (c1744-1788)|
|Spencer Douglas-Hamilton (1742-1791)|