Francis Sacheverel Darwin was born 17 June 1786 in Radbourne, Derbyshire, England, United Kingdom to Erasmus Darwin (1731-1802) and Elizabeth Collier (c1747) and died 6 November 1859 Breadsall, Derbyshire, England, United Kingdom of unspecified causes. He married Jane Harriet Ryle (1794-1866) 16 December 1815 in St. George, Hanover Square, London, England, United Kingdom.
Children
| Name | Birth | Death | Joined with |
| Mary Jane Darwin (1817-1872) | |||
| Reginald Darwin (1818-1892) | |||
| Emma Elizabeth Darwin (1820-1898) | |||
| Edward Levett Darwin (1821-1901) | 12 April 1821 Buxton, Derbyshire, England, United Kingdom | 23 April 1901 Buxton, Derbyshire, England, United Kingdom | Harriett Jessopp (1825-1889) |
| Frances Sarah Darwin (1822-1881) | |||
| Georgiana Elizabeth Darwin (1823-1902) | |||
| Violetta Harriot Darwin (1826-1880) | |||
| Ann Eliza Thomasine Darwin (1828-1904) | |||
| Millicent Susan Darwin (1833-1899) | |||
| John Robert Darwin (1835-1899) | |||
