Ephraim Wheeler was born 26 April 1678 in Concord, Middlesex County, Massachusetts to Thomas Wheeler (1621-1704) and Sarah Beers (1639-1724) and died 19 April 1725 Plainfield, Hampshire County, Massachusetts of unspecified causes. He married Elizabeth Spalding (1680-1724) 20 April 1698 in Chelmsford, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Edward Wheeler (1698-) | |||
| Elizabeth Wheeler (1699-1725) | 1695 Connecticut, United States | 3 October 1725 Norwich, New London County, Connecticut, United States | Matthew Huntington (1694-1756) |
| Ephraim Wheeler (1702-1755) | |||
| Benjamin Wheeler (1703-1770) | |||
| Olive Wheeler (1704-1772) | |||
| Thomas Wheeler (1706-) | |||
| Sarah Wheeler (1712-1724) | |||
| Edward Wheeler (1715-1797) | |||
| Mary Wheeler (1720-1825) | |||
Siblings
| Name | Birth | Death | Joined with |
| Sarah Wheeler (1649-1717) | |||
| Anne Wheeler (1653-1676) | |||
| John Wheeler (1655-1736) | 18 February 1655 Concord, Middlesex County, Massachusetts, United States | 1 December 1736 Concord, Middlesex County, Massachusetts, United States | Sarah Stearns (1661-1727) |
| Mary Wheeler (1658-1668) | |||
| Ephraim Wheeler (1660-1690) | |||
| Elizabeth Wheeler (1664-1744) | |||
| Timothy Wheeler (1667-1718) | |||
| Rebecca Wheeler (1670-1710) | |||
| Ruth Wheeler (1673-) | |||
| Mark Wheeler (1676-) | |||
| Name | Birth | Death | Joined with |
| Ephraim Wheeler (1678-1725) | 26 April 1678 Concord, Middlesex County, Massachusetts | 19 April 1725 Plainfield, Hampshire County, Massachusetts | Elizabeth Spalding (1680-1724) |
| Joanna Wheeler (1681-) | |||