Charles Russell Lowell II was born 20 October 1807 in Cambridge, Middlesex County, Massachusetts, United States to Charles Russell Lowell (1782-1861) and Harriet Bracket Spence (1783-1850) and died 22 June 1870 Boston, Suffolk County, Massachusetts, United States of unspecified causes. He married Anna Cabot Jackson (1811-1874) 18 April 1832 in Boston, Suffolk County, Massachusetts, United States.
Children
| Name | Birth | Death | Joined with |
| Anna Cabot Jackson Lowell (1833-1906) | |||
| Charles Russell Lowell (1835-1864) | 2 January 1835 Boston, Suffolk County, Massachusetts, United States | 20 October 1864 Middletown, Frederick County, Virginia, United States | Josephine Shaw (1843-1905) |
| Harriett Lowell (1836-1920) | 11 September 1836 Boston, Suffolk County, Massachusetts, United States | 20 January 1920 Boston, Suffolk County, Massachusetts, United States | George Putnam (1834-1912) |
| James Jackson Lowell (1837-1862) | |||
Siblings
| Name | Birth | Death | Joined with |
| Charles Russell Lowell (1807-1870) | 20 October 1807 Cambridge, Middlesex County, Massachusetts, United States | 22 June 1870 Boston, Suffolk County, Massachusetts, United States | Anna Cabot Jackson (1811-1874) |
| Rebecca Russell Lowell (1809-1872) | |||
| Mary Lowell (1810-1898) | |||
| William Keith Spence Lowell (1813-1823) | |||
| Robert Traill Spence Lowell (1816-1891) | |||
| James Russell Lowell (1819-1891) | |||