August von Anhalt-Plötzkau was born 14 July 1575 in Dessau, Saxony-Anhalt, Germany to Joachim Ernst von Anhalt-Dessau (1536-1586) and Eleonore von Württemberg (1552-1618) and died 22 August 1653 Plötzkau, Saxony-Anhalt, Germany of unspecified causes. He married Sibylle zu Solms-Laubach (1590-1659) 25 January 1618 in Ansbach, Bavaria, Germany. Charlemagne (747-814)/s, Henry II of England (1133-1189)/s, Hugh Capet (c940-996)/s.
In 1586, after the death of his father, Augustus inherited Anhalt jointly with his half- and full brothers under the regency of the eldest, John George I.
After seventeen years of joint rule, the surviving brothers agreed to a formal division of their lands in 1603. Augustus received Plötzkau, which was created from parts of the old principality of Anhalt-Bernburg.