Anne Spencer was born 5 November 1773 to George Spencer, 4th Duke of Marlborough (1739-1817) and Caroline Russell (1743-1811) and died 7 August 1865 of unspecified causes. She married Cropley Ashley-Cooper, 6th Earl of Shaftesbury (1768-1851) 1796 .
|Offspring of Cropley Ashley-Cooper, 6th Earl of Shaftesbury and Anne Spencer (1773-1865)|
|Harriet Anne Ashley-Cooper (1798-1868)||15 September 1798||25 March 1868||Henry Thomas Lowry-Corry (1803-1873)|
|Anthony Ashley-Cooper, 7th Earl of Shaftesbury (1801-1885)||28 April 1801 Mayfair, Greater London, England, United Kingdom||1 October 1885 Folkestone, Kent, England, United Kingdom||Emily Caroline Catherine Frances Cowper (1810-1872)|