Humpty Dumpty Tool (Borland Genetics)

The Humpty Dumpty tool in the Borland Genetics toolkit combines three related tools, each of which performs a merge operation on selected DNA resources.

The first option is to merge Mono to Mono. This option should be used whenever merging Mono output from contributors within a single clade (with respect to the target of reconstruction). When segments overlap among contributors, the result is typically dramatically increased resolution over the overlapping reconstructed segments as approximately half of the no-calls from one contributor will occur at different locations as the no-calls from another. No-call data from one contributor is replaced by data from the other where available. Where contributors’ reconstructions are inconsistent (usually near a poorly defined segment tip, or in the case of a random mutation, or when a small IBC or endogamous segment arises), the tool uses an algorithm to select the data values that have the highest probability of being accurate.

The second option is merge Mono to Stereo. This option should ONLY be used when merging Mono resources from separate sibling clades into a single Stereo kit, i.e. at the final stage of reconstruction. It is recommended that the Mono to Mono options for merger within a clade be exhausted before the final Mono to Stereo merge for optimal output resolution, and to take advantage of the intelligent handling of Mono merge conflicts in the Mono to Mono option.

The third and final option is for donors who have tested with more than one testing company who wish to combine their results into a single high resolution output kit on a combined template.