Imputer Tool (Borland Genetics)

The new Imputer tool in the Borland Genetics toolkit allows users to easily add to “Stereo” reconstructions, segments of DNA not inherited by the target’s descendants using “Mono” grandparent data imputed during a visual phasing process. Users must set a confidence threshold ranging from 75% to 99% with respect to the estimated accuracy of the imputed segments. This process is now automated and has a visualization interface to monitor effectiveness. This tool is the first to incorporate Borland Genetics’ new “Crude Mary” polynomial tensor Marey Map of the human genome which rapidly approximates cM values between selected start and end positions on a chromosome. In future versions, the Imputer tool will work in conjunction with the Creeper, which will recommend which segments to impute from which sibling clades based on a tree structure associated with the project.